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KMID : 0361019920350050688
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Korean Journal of Otolaryngology - Head and Neck Surgery
1992 Volume.35 No. 5 p.688 ~ p.693
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The Audiological Evaluation of Cis-platimum Induced Hearing Loss
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전재기
김철수/고의경/왕수건/전경명
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Abstract
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Cis-platinum induced hearing loss has been reported to be high tone hearing loss over 2 to 8 kHz. This study examined serial audiometry data from 75 patient treated with Cisplatinum for evaluation of the ototoxic effects of this drug.
@ES The results were as follows:
@EN 1) Patients showing hearing loss above 15 dB comparing to pretreatment were 37 cases(49.3%), and most of them had hearing loss below 25 dB.
2) Most cases showed hearing loss over 4kHz to 8kHz range, and the highest incidence of the maximum hearing loss was 8kHz in frequency.
3) The degree of hearing loss had no relation to the dosage of Cis-platinum, and the average dosage of the drug inducing hearing loss over 15dB was 178mg.
4) All cases showing hearing loss had manifested within 4 days.
5) No typical peripheral vertigenous symptoms were found.
6) In conclusion. Cis-platinum induced hearing loss is mild in degree in high frequency. Over 2 KHz, early manifested within 4 days, and not related with the dosage or vestibulotoxicity.
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